We analyze various biological phenomena exhibited by ES cells and iPS cells, particularly through the utilization of forward genetics. Forward genetics is a method that allows researchers to explore the function of genes without arbitrary intervention. Based on unexpected discoveries obtained with this method, we aim to develop new research fields.
What's New
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- September 22, 2025
- We have reported the role of N-myristoyltransferase as a novel mechanism regulating the pluripotency of mouse ES cells and human iPS cells (Yoshida et al., Stem Cell Reports）. This finding was derived from phenotypic analyses of the homozygous mutant mouse ES cell bank that we previously established.
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- Apr 17, 2025
- Updated Member
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- April 23, 2024
- We have reported that a genetic mutation in Smarce1, one of the subunits of the chromatin remodeling complex, induces chromatin instability in mouse ES cells（Kashiwagi et al., J Cell Sci). This finding was discovered through screening the homozygous mutant mouse ES cell bank that we previously reported. It is featured in the Research Highlights of the same issue.
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- December 1, 2021
- The website of Department of PhysiologyⅡ was renewed.
